The objective is to the study the Interactions between thyroid hormones and kidney functioning may coexist. The aim of this study was to investigate the renal function status in perimenopausal women with hypothyroidism. Total 60 perimenopausal women (30 cases and 30 controls) were recruited for the study. Thyroid hormones including thyroid stimulating hormone, thyroxin, and triiodothyronine were estimated by means of enzymelinked immunosorbent assay.